Muscimol HCI Salt (Water Soluble Muscimol Isolate)

Muscimol is a potent psychoactive compound that acts as a GABA agonist, meaning that it enhances the activity of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. It is a naturally occurring substance found in various species of mushrooms, including amanita muscaria, and has been used for its psychoactive properties in traditional medicine and shamanic rituals.

Muscimol is known to induce sedation, relaxation, and altered states of consciousness, and has been studied for its potential therapeutic applications in the treatment of neurological and psychiatric disorders.

The muscimol we create synthetically is the HCl (Hydrochloride) salt of muscimol and should be referred to as Muscimol HCl. The reason that we make the HCl salt is due to stability issues that occur in the freebase. The freebase is very pH sensitive and will degrade quickly if not handled and formulated properly. The Muscimol HCl is a charged form of muscimol that is stabilized by the chloride anions; when it is dissolved in water, the Muscimol HCl will dissociate into salt and pure muscimol. However, it is important to note that this means that 1mg of Muscimol HCl will not make a 1mg muscimol gummy. This is because of the presence of the salt in the raw powder. For calculation purposes, please use the following information:

Muscimol = 114.1g/mol
H+ = 1g/mol
Cl- = 35.45g/mol

Muscimol HCL = 150.55g/mol
Muscimol = 114.1g/mol
HCl = 36.45g/mol

114.1g/mol / 150.55g/mol = 75.83% Muscimol

36.45g/mol / 150.55g/mol = 24.16% Salt

758.3mg/g of Active Muscimol for Each Gram of Muscimol HCl

This would mean that to make a 5mg Muscimol Gummy using Muscimol HCl you would need to formulate 6.59mg of Muscimol HCl.

5,000 ug Muscimol / 758.3ug/mg Muscimol = 6,590mg of Muscimol HCl